Usefulness of monitoring linezolid trough serum concentration in prolonged treatments.
نویسندگان
چکیده
Linezolid has proven valuable in musculoskeletal infections, however, failure and resistance have been described and toxicity is worrisome when more than 28 days are necessary. We describe the first 5 cases in whom linezolid trough serum concentrations were weekly measured and its relationship with clinical outcome and toxicity.
منابع مشابه
Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study
INTRODUCTION Severe infections in intensive care patients show high morbidity and mortality rates. Linezolid is an antimicrobial drug frequently used in critically ill patients. Recent data indicates that there might be high variability of linezolid serum concentrations in intensive care patients receiving standard doses. This study was aimed to evaluate whether standard dosing of linezolid lea...
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Arena et al. describe in this issue a case of a young patient admitted to the intensive care unit for an acute subdural hematoma who developed bacteremia due to Enterococcus faecalis under linezolid treatment (1). They measured linezolid concentrations after 6 h of the last administration on 2 occasions, and both were close (2.13 mg/liter) or below (1.47 mg/liter) the MIC of E. faecalis (2 mg/l...
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Sir, Linezolid, a new oxazolidinone, has a unique mode of action.1 The antimicrobial agent has a wide spectrum of activity against Gram-positive organisms, including methicillinresistant Staphylococcus aureus,2,3 penicillin-resistant pnemococci3 and both vancomycin-resistant Enterococcus faecalis and Enterococcus faecium.3,4 Linezolid is available in oral and intravenous (iv) preparations and n...
متن کاملLinezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis
Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational competence of mitochondria isolated from peripheral blood of participants by determining the cytochrome c oxidase/citrate synthase activity ra...
متن کاملLinezolid clearance during continuous venovenous hemodiafiltration: a case report.
OBJECTIVE To determine the linezolid clearance and serum concentrations in a critically ill man receiving continuous venovenous hemodiafiltration (CVVHDF). METHODS Intravenous linezolid 600 mg every 12 hours was administered to a critically ill, 85-year-old man with anuria who was receiving CVVHDF at a dialysate flow rate of 2000 ml/hour and a mean ultrafiltrate production rate of 775 ml/hour...
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ورودعنوان ژورنال:
- Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
دوره 24 3 شماره
صفحات -
تاریخ انتشار 2011